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Low B12 levels are increasingly common, especially in people following vegan or vegetarian diets, those with absorption issues, or individuals experiencing tiredness, low mood, or brain fog

For example, it has been studied as an adjunctive treatment in certain neurological conditions (such as schizophrenia) owing to its activity in the central nervous system.It has also been utilized historically in diagnostic provocation tests (e.g., to stimulate growth-hormone release) and as an irrigating fluid in surgical settings (in much more diluted form)