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In 2014, a paper in the *Journal of Pharmacology and Experimental Therapeutics* laid out dihexa's proposed mechanism that it works by binding hepatocyte growth factor and activating the c-Met system to build synapses

Under extreme iodine exposure, the thyroid gland may also exhibit aberrant expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptor (DR)-5, resulting in follicular cell apoptosis

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