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SKU: 72312383711

4.2
USD24.34 USD61.34

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Description

FOXO4-DRI acts as a competitive inhibitor of this interaction binding directly to the transactivation domain 2 (TAD2) of p53, displacing FOXO4, and allowing phosphorylated p53 to be exported from the nucleus and directed to mitochondria, where it activates BAX, triggers caspase-3 cleavage (via the p53/BCL-2/Caspase-3 signalling pathway), and drives cell-intrinsic apoptosis

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In fact, a significant reduction of cell viability was observed after illumination with LEDs at 405 nm on both tested H

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