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By addressing these research gaps, future studies can refine clinical guidelines, develop precision-targeted interventions, and establish standardized methodologies that maximize the therapeutic benefits of exercise and polyphenol supplementation for depression and cognitive resilience

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[9], we collected some of these compounds: in brief, we defined the beneficial effects of the following: of anakinra and anti-IL-1b monoclonal antibodies (Mabs) in inhibiting the IL1-b/IL-1R1 axis

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