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Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochemical Pharmacology , 163, 481-492

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As NAD+ supplementation research has expanded dramatically, the discovery that NNMT depletes NAD+ precursors specifically in metabolically dysfunctional fat tissue provides a targeted intervention point

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doi:10.1038/nature13198

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It supports the production of red blood cells, helps maintain a healthy nervous system, and is required for DNA synthesis

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