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By persistently activating GLP-1 receptors, these drugs provide a constant signal of fullness to the brain, leading to a significant reduction in calorie intake and subsequent weight loss

1995 Jun;27(3):237-53

doi: 10.1001/jamapediatrics.2022.4401

The compounding industry argued, not unreasonably, that the restrictions had driven patients toward unregulated gray-market sources: overseas chemical suppliers operating under "research use only" labels with no quality controls, no dosage verification, and no pharmaceutical oversight