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These would include, for example, antacid medications that inhibit the bodys production of stomach acid, anti-cholesterol medications that block the production of cholesterol, and selective serotonin reuptake inhibitors (SSRIs) that block the uptake of serotonin to treat depression

Vesicular glutamate transporters have a much lower affinity for glutamate 0.5-3.5 mM than plasma membrane transporters GLT1/EAAT2, whose Km is 4-40 M (25, 26)

A novel approach to AD drug development is therefore critical

Conclusions In summary, our study constructed an AD-related pathway-gene network and identified (-)-Vestitol and Salviolone as novel candidate natural products for AD treatment