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Once inhaled, smoke causes the release of the many different chemicals in ones body, disrupting the mechanism in the lungs that would normally protect it from injury brought about by tobacco smoke

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5B, pathway enrichment analysis using the 1238 metabolic features from cluster 7 generated eight pathways including N -glycan biosynthesis ( p = 0.012), porphyrin metabolism ( p = 0.015), glycosphingolipid biosynthesis ( p = 0.02), bile acid biosynthesis ( p = 0.022), leukotriene metabolism ( p = 0.031), prostaglandin formation ( p = 0.031), blood group biosynthesis ( p = 0.031), and arachidonic acid metabolism ( p = 0.034)