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In rodent models , it has shown the ability to support gut integrity and reduce inflammation-related responses

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A large-scale study was conducted as a follow-up to an original 5-year study, which found use of a daily antioxidant supplement containing beta-carotene, vitamin C, vitamin E, zinc and copper reduced the risk of progressive AMD by 25 percent among participants with early and intermediate macular degeneration

A 12-week study involving 50 participants with melasma found that a combined niacinamide and glutathione regimen reduced melanin index scores by up to 38% , compared to just 19% for niacinamide alone