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[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility

The combination effect becomes clearly apparent

Functions: The role of B vitamins in the body is impressive as they are involved in metabolism, skin health, immune and nervous system functions, muscle tone, and the prevention of anemia