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Research suggests that oral melatonin, at doses of 25 mg taken at night, can significantly reduce the Melasma Area Severity Index (MASI) score

Specifically, it upregulates specific microRNAs (miRNAs) to silence the expression of two critical molecules: miR-155, miR-181b, and miR-361 target Aicda, whereas miR-23b, miR-30a, and miR-125b target Prdm1 (encoding B lymphocyte-induced maturation protein-1, Blimp-1)

State Topical formulation Storage Per product label Notes Compounded topicals follow the compounder's beyond-use date