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However, both mTOR and GSK3 upstream are the negative regulators of autophagy leading to failure of autophagy as in Lafora disease which is an autosomal recessive epilepsy characterized by resistance epilepsy and dementia (Lohi et al

Its metabolism is closely linked to the transsulfurization branch (providing cysteine), the GSH-GSSG redox cycle (maintaining redox balance), and the detoxification system (completing substance detoxification), forming a complex and efficient metabolic network

doi: 10.3389/fendo.2022.962635 231 XiongJHuHGuoRWangHJiangH

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