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Piperine, frequently combined with curcumin to enhance its bioavailability, is a relatively selective non-competitive inhibitor of CYP3A, and also affects CYP1A1, 1B1, 1B2, and 2E1, further contributing to this interaction profile [72]

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Tight junctions restrict paracellular diffusion, while transport proteins and efflux pumps such as ATP-binding cassette (ABC) transporters actively remove compounds entering endothelial cells

doi: 10.1183/09031936.00006911