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Description

This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

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Starup-Linde J, et al

For example, free heme triggers macrophage Toll like receptor 4 (TLR4) activation and TNF- production, as well as ROS-mediated NLRP3 inflammasome induction (6770)