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Side effect profiles in research also differ

Finally, we briefly describe how the GH/IGF-I axis is impacted by liver disease, weight loss, GH misuse for recreational and athletic performance-enhancing, GH-releasing hormone (GHRH) analog use in HIV lipodystrophy, and the alterations of the GH/IGF-I axis in subjects with congenital isolated GH and IGF-I deficiencies

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In animal studies, it affects angiogenesis (blood vessel formation), collagen organization, and growth factor modulation through pathways including EGR-1 gene upregulation