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Third, long-term safety and efficacy data beyond several months of treatment is lacking

Mechanistically, EPA and DHA integrate into platelet membranes and displace arachidonic acid, thereby shifting the eicosanoid balance toward increased prostacyclin (PGI 2 ) and reduced thromboxane A 2 (TXA 2 ) synthesis (248)

Moreover, previous studies have demonstrated that NLRP3 inflammasome was activated in myocardial I/R injury in cardiac microvascular endothelial cells (16), cardiac fibroblasts (17), which indicates a role of NLRP3 inflammasome in the development of myocardial injury

It is studied in controlled models only