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To further confirm whether AMPK inhibition influences metformin-induced GLUT1 upregulation, AMPK was knocked down using small interfering RNA (siRNA) as an alternative approach to pharmacological inhibition

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To date, there is not much known about how tightly the rates at which these metabolic pathways function are linked to the level of CoQ in the IMM or whether an impact on these pathways contributes to the pathophysiology of CoQ deficiency