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The acetylation level of each lysine residue of the histones is determined by the balance between two types of enzymes: histone acetyltransferases (HATs) and histone deacetylases (HDACs)

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Although these findings do not completely exclude the effect on kidney parenchymal cells or off-target effects, these results suggest that sulfasalazine prevents the formation of TLS not by attenuating tubular injury but via its inhibitory effect on of the cystine/glutamate transporter specifically expressed within TLS