Comparing the extremes (methionine versus albumin as target or detector) shows that there is a large difference in the contribution of the oxidation products of GSH in the overall protection against the HOCl-induced damage to either methionine or albumin by GSH
These disruptions lead to excessive lipid ROS accumulation, resulting in cellular damage and matrix degradation
Peng, F, Sinjab, A, Dai, Y, Treekitkarnmongkol, W, Yang, S, Gomez Bolanos, L, Zhou, T, Chen, M, Serrano, A, Krishna, A, Karimi, N, Sharma, M, Basi, A, Pei, G, Liao, J, Liu, Y, Feng, J, Rahal, Z, Liu, Y, Jiang, J, Yu, K, Noun, T, Liu, Y, Khan, KB, Cho, KS, Chen, J, Solis Soto, LM, Mazzilli, SA, Dubinett, SM, Cascone, T, Spira, A, Swisher, SG, Jimbo, N, Hayashi, T, Kishikawa, S, Takamochi, K, Itoh, T, Yao, T, Suzuki, K, Kalhor, N, Wistuba, II, Li, M, Moghaddam, SM, Fujimoto, J, Burks, JK, Myers, JN, Akdemir, KC, Wang, L , Kadara, H
diet, etc