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Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall

In addition, a newer class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated cardioprotective properties in trials with individuals who have diabetes and CKD, as well as people with CKD who do not have diabetes

Accessed August 9, 2022

Nelson DB, Mitchell KG, Weston BR, Betancourt S, Maru D, Rice DC, Mehran RJ, Sepesi B, Antonoff MB, Walsh GL, Swisher SG , Roth JA, Vaporciyan AA, Blum M, Hofstetter WL