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Modulating the activity of matrix metalloproteases and their inhibitors: This modulates the breakdown and remodelling of skin components during healing [2]

The activation occurs via trans -phosphorylation of two catalytic tyrosines (Y1234 and Y1235) located in the kinase domain, followed by the subsequent auto-phosphorylation of the two docking tyrosines (Y1349 and Y1356) in the C-terminal tail