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"Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance"

B12 supplements should be avoided by those with known cobalt sensitivity and used with caution in people with Leber's hereditary optic neuropathy

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease

Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome