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In mammalian cells, ER stress leads to an integrated stress response involving the related transmembrane kinases Ire1, Ire1 and PKR-like ER kinase (PERK), and the transmembrane activating transcription factor 6 (ATF6) (Zhang & Kaufman, 2004)

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ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets

This shift is supported by the following facts and conclusions from past findings: (1) -amyloid-induced plaques and neurofibrillary tangles define AD but may not cause it