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Previous study ( Alkaloid Sinomenine Sinomenine is the main active ingredient isolated from the Chinese medicinal Caulis Sinomenii for the treatment of rheumatic diseases, and has the biological effects of anti-inflammation, anti-oxidation, inhibition of apoptosis, immunosuppression, etc ( Ser351 to degrade Keap1 and increase Nrf2 expression, and play a role in protecting bone destruction by increasing p62 expression and activating the p62-Keap1-Nrf2 axis through p62 Thr269/Ser272 phosphorylation

These conditions can result from various factors, such as infections, genetic predispositions, autoimmune diseases, environmental triggers, or other underlying causes

8 Streptozotocin (STZ), a glucose analog derived from Streptomyces achromogenes , selectively targets and destroys pancreatic beta cells in rodent models, serving as a widely utilized tool for inducing experimental diabetes

Mouse models of intestinal cancer