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Native IGF-1 has very high affinity for these binding proteins, with over 99% of circulating IGF-1 bound to IGFBPs, very IGFBP-3

Acta Ophthalmologica 94:S256

Thus, for promotion of participation in RT in older adults, lower intensity, machine-based exercise led by qualified exercise professionals is critical for safe implementation of RT (Fragala et al., 2019)