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This paradoxthat patients with higher baseline severity showed higher rates of MELD-3 improvementis compatible with several mechanisms, including (but not limited to) a possible therapeutic effect of glutathione in inflammation-rich states, control of the precipitating event by concurrent standard care, and statistical regression toward the mean

1 Introduction Neurodegenerative diseases (NDDs) comprise a heterogeneous group of disorders characterized by the progressive loss of neurons or myelin in the brain and spinal cord, including Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntingtons disease (HD) (Wilson et al., 2023)

Alexa Fluor 488 annexin V/dead cell apoptosis kit was purchased from Invitrogen (Carlsbad, CA, USA)

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