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Conversely, TP53 can suppress ferroptosis by inhibiting dipeptidyl peptidase 4 (DPP4) activity or inducing cyclin dependent kinase inhibitor 1A ( CDKN1A , also known as p21) 157,158

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It also penetrates the skin barrier 4 times better than magnesium ascorbyl phosphate, and delivers vitamin C to the skin 50 times better than ascorbic acid 14

In particular, nano-formulation strategiesincluding polymeric nanoparticles, lipid-based nanocarriers, nanoemulsions, and micellar systemshave shown promise in improving solubility, stability, and pharmacokinetic behavior