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Extended protocols beyond typical 8-12 week durations appear safe based on available evidence

For instance, angiotensin-converting enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs are used as an effective first-line therapy

There are a number of well established risk factors for the development of ischemic stroke including diabetes mellitus, atrial fibrillation, hypertension and age [2]

Studies have reported OCTN2 expression in respiratory epithelial cells and alveolar macrophages, which is especially high in the upper lung region [301], and OCTN2-mediated carnitine uptake plays an important role in maintaining respiratory cilia beating and airway mucociliary clearance function, helping to remove excess mucus and potentially harmful substances from the airway [302]