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Anastomoses between two defects in the corresponding tissues (i.e., in esophagus and skin (Cesarec et al., 2013), stomach and skin (Skorjanec et al., 2009), duodenum and skin (Skorjanec et al., 2015), colon and skin (Klicek et al., 2008), colon and bladder (Grgic et al., 2016), and rectum and vagina (Baric et al., 2016)) depict the various fistulas (Sikiric et al., 2020a)

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Completed human trials establishing safety and efficacy would enable consideration for approval pathways