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Direct injection can damage peptide structure through mechanical stress

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All animal studies were approved by the local animal care authorities, Landesamt fr Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen (LANUV), NRW, Germany (AZ: 2018.A030 and 2016.A212) and conformed to the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes

Casas AI, Dao VT, Daiber A, Maghzal GJ, Di Lisa F, Kaludercic N, Leach S, Cuadrado A, Jaquet V, Seredenina T, Krause KH, Lpez MG, Stocker R, Ghezzi P, Schmidt HH (2015) Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications