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Occasional minor irritation during adaptation is normal, but ongoing redness, sensitivity, or discomfort indicates problems

137 The intrinsic reactivity and peculiar chemistry of per-sulphides and poly-sulphides indicate that they might carry out numerous signalling functions that could currently be underestimated mainly owing to the technical difficulties in studying these metabolites in biological milieu

Reconstituted solutions should be stored at 28C and used within 30 days

Platforms obtained in this manner retain the specificity of TME-oriented design yet remain relatively compatible with existing pathways for manufacturing, quality control and safety assessment in drug development [61,62,63]