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Emerging therapeutic applications investigating nicotine's neuroprotective effects in Parkinson's disease and mild cognitive impairment trials require additional specifications including enantiomeric purity assays to confirm the predominance of the pharmacologically active (S)-nicotine isomer above 98.5% of total nicotine content

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Nerve damage or irritation A cause of long-term hiccups is damage to, or irritation of, the vagus nerves or phrenic nerves

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