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Oxidative stress can result from the presence of persistent organic pollutants, metals, pesticides, toxins, pharmaceuticals, and nanomaterials, as well as changes in temperature or oxygen in water, the examined species, with differences in age, sex, or reproductive cycle of an individual

Indeed, it has been observed that CD38 levels increase significantly during aging, with an increased consumption of NAD contributing to NAD reduction during aging

found that Zicuiyin decoction reduced serum creatinine levels in patients with DKD, accompanied by an increased abundance of Prevotellaceae and Lactobacillaceae and a decreased abundance of Enterobacteriales, Clostridiaceae, and Micrococcaceae ( Table 3 ) [189]

doi: 10.3389/fpsyt.2019.01016