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All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA)

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Given the activation of receptors as the only direct action of a neurotransmitter, beta-endorphin is a relatively well-known example of a peptide neurotransmitter primary transmitter at a synapse having highly specific interactions with opioid receptors in the central nervous system [34,35]