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Hansen H, Filippa DA, Andreeff M , Fried J, Arlin Z, Clarkson B

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L'ARA-290 (cibinetide) is an 11-amino-acid peptide that selectively activates the EPO-R/CD131 (innate repair receptor) complex without stimulating erythropoiesis or increasing hematocrit

Therapeutics that block RSL3-mediated GPX4 inactivation may provide a targeted approach to preserving antioxidant capacity in ARDS patients, reducing the extent of ferroptosis-driven lung damage ( 5.3 Iron chelators Iron overload exacerbates ferroptosis by fueling ROS production and lipid peroxidation, making iron chelation a viable therapeutic approach