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Soluble Vpr released from infected microglia activates HIF-1 and perturbs neuronalglial homeostasis, driving oxidative stress, elevation of intracellular Ca, excess ROS, and disruption of neuronal glutamatergic signaling [135, 136]

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Peptide therapeutics: current status and future directions

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69-72 The clinical history should include questions about symptom duration

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