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Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve

The medication and alternative therapy use among participants also decreased significantly, suggesting that GLP-1 medications may reduce the need for additional symptom management strategies

To match this call for inclusivity, trial design must also evolve, adopting adaptive and master protocols that reflect the complexity of neurodegeneration in the real world