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Angiogenic AcSDKP generation Prolyl oligopeptidase cleaves TB4 and releases the tetrapeptide Ac-Ser-Asp-Lys-Pro, an autonomous angiogenic factor layered on top of TB4's direct effect on endothelial migration

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Animal and cell-culture studies point to three overlapping pathways: promotion of angiogenesis (new blood-vessel formation, linked to VEGF), support for collagen and tendon repair, and anti-inflammatory effects

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