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Journal of gastroenterology

5a), the blood glucose levels in fed conditions were significantly lower than those of un-transplanted Insr P1195L/ +/HFD mice at 14 and 16 weeks of age (Fig

Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development

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