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In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

5 amino 1MQ (NNMTi) is a small molecule compound that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in energy metabolism and fat storage