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They found that genetically reducing mast cells in mice completely prevented osteoarthritis

(PubMed) Lindeman RD, Romero LJ, Koehler KM, et al

Markun S, Scherz N, Rosemann T, Tandjung R, Braun RP

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ME/CFS is defined as persistent or relapsing fatigue for at least six months, which is not resolved by rest, and causes a substantial reduction in the Activity of Daily Living (ADL) 206