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Glutathione deficiency increases susceptibility to oxidative stress, which may be the underlying cause of many diseases including cancer, heart disease, Parkinsons, and Alzheimers

10.1371/journal.pone.0078636 101 MohamadN.-,v.SoelaimanI.-N.ChinK.-Y

However, scientific research shows that very high-dose oral B12 (1,000-2,000 mcg) can be effective for some, as about 1% can be absorbed without intrinsic factor