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Mood changes mild depressive symptoms and low mood occur in 411% of patients taking Roaccutane, while severe depression is rare at less than 1%
It is estimated that one case of DRESS occurs for every 10,000 drug exposures, particularly anticonvulsants such as carbamazepine.11,12 Among antituberculosis drug users, DRESS occurs in 1.2% of the patients.13 In a retrospective study of 1,253 adult patients receiving antituberculosis drugs between 2006 and 2010, 15 cases (1.2%) of DRESS were observed, in patients with a mean age of 65 years (4874), 53.3% men, with ethambutol being the most used agent (53.5%), followed by rifampicin (26.5%), pyrazinamide (20.0%), streptomycin (13.3%) and isoniazid (6.7%), with a mean latency period of 42 days for developing symptoms and signs of DRESS.14 There is no clear gender predilection among cases of DRESS syndrome
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