Subbaramaiah K, Yoshimatsu K, Scherl E, et al
Full-length growth hormone contains 191 amino acids with specific regions responsible for receptor binding (Sites 1 and 2, located in the N-terminal and middle portions of the molecule)
However, in GDH 1 knock-out mice (only humans express GDH 2) most functions, except the already mentioned reduced glutamate oxidation in cultured astrocytes, are remarkably intact (Frigerio et al., Table 2 Oxygen consumption rates as indications of kinetics of glutamate-dehydrogenase and aspartateglutamate transferase activities in non-synaptic mitochondria from the rat
Brenna A, Olejniczak I, Chavan R, Ripperger JA, Langmesser S, Cameroni E, et al