It defends against dryness, chemical harm, and low body temperature, while also protecting the body against harmful pathogens through a multifaceted innate immune response and microbiome ( Figure 1 The elderly population is particularly affected by type 2 inflammatory skin diseases, such as atopic dermatitis (AD), chronic spontaneous urticaria (CSU), and bullous pemphigoid (BP), which are believed to be linked to skin immunosenescence ( In this manuscript, we introduce the structure of the skin, the mechanism of skin aging, the composition of the microenvironment of aging skin, and the role of aging in various skin diseases, providing a new perspective for targeting aging-related mechanisms to treat skin diseases in clinical practice
Background BPC-157 was initially synthesized in the early 1990s and studied for its cytoprotective properties as an anti-ulcer agent
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