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Bonnie Springs at Hines Hospital, VA Medical Center, gave depressed and non-depressed subjects either nicotinized or denicotinized cigarettes after introducing a positive mood trigger and found that [s]elf-administering nicotine appears to improve depression-prone smokers emotional response to a pleasant stimulus. To investigate further, researchers at the University of Pittsburgh studied whether or not cigarettes improve emotional response to stressful triggers such as preparing for public speaking, dealing with a difficult computer task, and seeing negative images

Its authors reported that smoking tobacco every single day was linked with both increased risk of psychosis and earlier age of onset of psychotic disorder