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Yes, a leaky gut can contribute to brain fog and fatigue

Melatonin is often referred to as the body's "sleep hormone," though it is more accurately described as a circadian signaling molecule that helps synchronize the sleep-wake cycle with environmental light and darkness and promotes sleep onset partly by lowering core body temperature

In 2012, another research team (Mazzarino et al., 2012) designed poloxamer modified NPs composed of PCL, and decorated the final nanoscaffolds with chitosan

It also plays a critical role in the livers detoxification processes, helping the body process and eliminate environmental toxins and metabolic waste