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In the context of intravascular hemolysis, free iron released locally can directly produce ROS through participation in Fenton reactions

The global IV hydration therapy market, valued at $2.3 billion in 2023, is a testament to its growing popularity

While preclinical models have yielded valuable insights into microglial heterogeneity, many markers defined in rodent systems [e.g., arginase 1 (Arg1) or rodent-specific chitinase-like protein (Ym1)] have limited expression or different regulation in human microglia