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Drug Enforcement Administration ranks controlled substances according to five schedules. Marijuana, along with drugs like heroin and LSD, is a Schedule I drug, meaning it is considered to have the highest potential for abuse and be the most dangerous. Because alcohol and tobacco are legal, they are not controlled substances, and not subject to DEA scheduling

Aside from the many substances in cigarettes that are toxic and hazardous for your health, theres also a highly addictive compound in them called nicotine

But to truly gain insight, we need to consider other information, too

1 2 3 "Patch testing in cutaneous adverse drug reactions: Methodology, interpretation, and clinical relevance"