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Initial effects moderate as regulatory systems recalibrate to the new normal

At the cellular level, the core clock genes, including Bmal1, Clock, Per, Cry , and Rev-Erb , play an important and vital role in maintaining physiological homeostasis

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This, in turn, may result in decreased infiltration of inflammatory cells into lung tissues in murine models, alongside lower levels of tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) production, further mitigating tissue damage